BAY-7081 | PDE9A inhibitor | Probechem Biochemicals

Chemical Structure : BAY-7081

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BAY-7081 (BAY7801)

货号: PC-49572Not For Human Use, Lab Use Only.

BAY-7801 (BAY7801) is a potent, selective, and orally bioavailable PDE9A inhibitor with IC50 of 15 nM (human PDE9A), 49-fold selectivity over PDE1.

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100 mg		Get quote

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生物&药学活性

BAY-7801 (BAY7801) is a potent, selective, and orally bioavailable PDE9A inhibitor with IC50 of 15 nM (human PDE9A), 49-fold selectivity over PDE1.
BAY-7801 also potently inhibits mouse and rat PDE9A with IC50 of 34 and 42 nM, respectively.
BAY-7801 displays >100-fold selectivity over other phosphodiesterases.
BAY-7801 showed an EC50 of 1 μM which favorably compares to 1.7 μM for PF-04447943 in cell-based assays.
BAY-7801 (10 mg/kg, 5 weeks) significantly reduced hypertrophy of the left atrium and improved the heart function in transverse aortic constriction mouse model.

物理化学性质&存储条件

分子量	362.902
分子式	C19H27ClN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ent-4-(6-Azaspiro[2.5]octan-6-yl)-2-oxo-8-propyl-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carbonitrile Hydrochloride

参考文献

1. Daniel Meibom, et al. J Med Chem. 2022 Dec 22;65(24):16420-16431.

BAY-7081 (BAY7801)

生物&药学活性

物理化学性质&存储条件

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BAY-7081 (BAY7801)

生物&药学活性

物理化学性质&存储条件

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