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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Elastase-BAY-678
BAY-678

Chemical Structure : BAY-678

CAS No.: 675103-36-3

BAY-678 (BAY678;BAY 678)

货号: PC-60473Not For Human Use, Lab Use Only.

BAY-678 (BAY678) potent, selective, cell permeable human neutrophil elastase (HNE) inhibitor with IC50 of 20 nM.

规格 价格 库存 数量
10 mg ¥1180 In stock
25 mg ¥1980 In stock
50 mg ¥3280 In stock
100 mg Get quote

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BAY-678 (BAY678) potent, selective, cell permeable human neutrophil elastase (HNE) inhibitor with IC50 of 20 nM.
BAY-678 displays >2,000-fold selectivity over a panel of serine proteases (IC50>30 uM).

物理化学性质&存储条件

分子量 400.361
分子式 C20H15F3N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-[(4R)-5-acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile

参考文献

1. von Nussbaum F, et al. ChemMedChem. 2015 Jul;10(7):1163-73.

2. von Nussbaum F, et al. ChemMedChem. 2016 Jan 19;11(2):199-206.

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