BAY-593 | YAP1/TAZ inhibitor | Probechem Biochemicals

Chemical Structure : BAY-593

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BAY-593 (BAY593)

货号: PC-22050Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote

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生物&药学活性

BAY-593 (BAY593) is a potent, selective, in vivo-active YAP1/TAZ pathway inhibitor with IC50 of 9.4 nM in TEAD-luciferase assays, directly tareget PGGT1B, a subunit of the geranylgeranyltransferase-I (GGTase-I) complex.
BAY-593 potently inhibits MDA-MB-231 and HT-1080 proliferation with IC50 of 564 and 38 nM respectively.
BAY-593 effectively promoted YAP1 inactivation by translocation to the cytoplasm with an IC50 of 44 nM.
BAY-593 dose-dependently down-regulates YAP1/TAZ target genes ANKRD1, CTGF, CYR61, CDC6, and DKK1.
BAY-593 effectively inhibits GGTase-I substrates of the Rho-GTPase family in MDA-MB-231 cells, and causes YAP1/TAZ inactivation.
BAY-593 impairs cancer cell proliferation and invasion in vitro with IC50 of <1 uM against a panel of cell lines from different tumor types.
BAY-593 (5 mg/kg, BID or QD; 10 mg/kg QD, p.o.) reduces tumor growth in MDA-MB-231 human breast cancer tumors in female NMRI nu/nu mice.

物理化学性质&存储条件

分子量	476.54
分子式	C26H31F3N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3,3,3-trifluoro-2-methoxy-1-((R)-7-(2-methoxyphenyl)-3,9-diazaspiro[5.5]undecan-3-yl)-2-phenylpropan-1-one

参考文献

1. Graham K, et al. Cell Chem Biol. 2024 Mar 19:S2451-9456(24)00087-4.

BAY-593 (BAY593)

生物&药学活性

物理化学性质&存储条件

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BAY-593 (BAY593)

生物&药学活性

物理化学性质&存储条件

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