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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-ROCK-BAY-549
BAY-549

Chemical Structure : BAY-549

CAS No.: 867017-68-3

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BAY-549 (BAY549, Azaindole-1, Azaindole 1)

货号: PC-42519Not For Human Use, Lab Use Only.

A potent, highly selective, ATP-competitive ROCK inhibitor with IC50 of 0.5/1.1 nM for ROCK1/ROCK2 respectively.

规格 价格 库存 数量
2 mg ￥1380 In stock
5 mg ￥2180 In stock
10 mg ￥3580 In stock
25 mg ￥5880 In stock
50 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BAY-549 (Azaindole-1) is a potent, highly selective, ATP-competitive ROCK inhibitor with IC50 of 0.5/1.1 nM for ROCK1/ROCK2 respectively.
BAY-549 (Azaindole-1) shows weak activity on Trk and FLT3.
BAY-549 (Azaindole-1) induced a dose-dependent decrease in blood pressure in vivo and orally active.

物理化学性质&存储条件

分子量 402.7852
分子式 C18H13ClF2N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,4-Pyrimidinediamine, 6-chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-

参考文献

1. Kast R, et al. Br J Pharmacol. 2007 Dec;152(7):1070-80.

2. Pankey EA, et al. Can J Physiol Pharmacol. 2012 Jul;90(7):825-35.

3. Lasker GF, et al. Urology. 2013 Feb;81(2):465.e7-14.

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