BAY-524 |CAS:1445830-39-6 Probechem Biochemicals

Chemical Structure : BAY-524

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BAY-524 (BAY524)

货号: PC-35362Not For Human Use, Lab Use Only.

BAY-524 (BAY524) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 450 nM.

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生物&药学活性

BAY-524 (BAY524) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 450 nM.
BAY-524 reduces T120 phosphorylation of histone H2A in intact cells, affects chromosome association of Shugoshin proteins and the chromosomal passenger complex (CPC), without abolishing global Aurora B function.
BAY-524 impairs chromosome arm resolution with minor effects on mitotic progression or SAC function.
BAY-524 sensitizes cells to Paclitaxel, impairing both chromosome segregation and cell proliferation.

物理化学性质&存储条件

分子量	482.492
分子式	C24H24F2N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

参考文献

1. Baron AP, et al. Elife. 2016 Feb 17;5. pii: e12187.

BAY-524 (BAY524)

生物&药学活性

物理化学性质&存储条件

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BAY-524 (BAY524)

生物&药学活性

物理化学性质&存储条件

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