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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Checkpoint Kinase (Chk)-BAY-524
BAY-524

Chemical Structure : BAY-524

CAS No.: 1445830-39-6

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BAY-524 (BAY524)

货号: PC-35362Not For Human Use, Lab Use Only.

BAY-524 (BAY524) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 450 nM.

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10 mg ￥2480 In stock
25 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BAY-524 (BAY524) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 450 nM.
BAY-524 reduces T120 phosphorylation of histone H2A in intact cells, affects chromosome association of Shugoshin proteins and the chromosomal passenger complex (CPC), without abolishing global Aurora B function.
BAY-524 impairs chromosome arm resolution with minor effects on mitotic progression or SAC function.
BAY-524 sensitizes cells to Paclitaxel, impairing both chromosome segregation and cell proliferation.

物理化学性质&存储条件

分子量 482.492
分子式 C24H24F2N6O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[1-(4-ethoxy-2,6-difluorobenzyl)-5-methoxy-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

参考文献

1. Baron AP, et al. Elife. 2016 Feb 17;5. pii: e12187.

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