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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-PPAR-BAY-4931
BAY-4931

Chemical Structure : BAY-4931

CAS No.: 423150-91-8

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BAY-4931 (BAY4931)

货号: PC-49399Not For Human Use, Lab Use Only.

BAY-4931 (BAY4931) is a potent, selective, covalent PPARγ inverse agonist with IC50 of 0.17 nM in cellular reporter assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BAY-4931 (BAY4931) is a potent, selective, covalent PPARγ inverse agonist with IC50 of 0.17 nM in cellular reporter assays.
BAY-4931 displays no signigicant acitivity against PPARA, PPARD and additional high homology PXR (IC50 values >50 uM).
BAY-4931 inhibits proliferation of PPARG-amplified cell line UM-UC-9 with IC50 of 3.4 nM.
BAY-4931 showed antiproliferative effects across UM-UC-9, HuP-T4, and PaCaDD-188 sensitive cell lines in the colony formation assays.

物理化学性质&存储条件

分子量 421.837
分子式 C22H16ClN3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-chloro-N-(2-(4-ethylphenyl)benzo[d]oxazol-5-yl)-5-nitrobenzamide

参考文献

1. Douglas L Orsi, et al. J Med Chem. 2022 Oct 21. doi: 10.1021/acs.jmedchem.2c01379.

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