BAY-405 | MAP4K1 inhibitor | Probechem Biochemicals

Chemical Structure : BAY-405

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BAY-405 (BAY405)

货号: PC-49661Not For Human Use, Lab Use Only.

BAY-405 (BAY405) is a potent, selective MAP4K1 (HPK1) inhibitor with IC50 of 6 nM in binding competition assays.

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生物&药学活性

BAY-405 (BAY405) is a potent, selective MAP4K1 (HPK1) inhibitor with IC50 of 6 nM in binding competition assays.
BAY-405 inhibits SLP76 phosphorylation with submicromolar potency (IC50=0.63 uM) and shows good kinase selectivity.
BAY-405 enhances T-cell immunity and overcomes the suppressive impact of PGE2, TGFβ and CD4+ T-regulatory cells.
BAY-405 demonstrated single-agent efficacy in syngeneic EMT6 breast and B16-OVA melanoma mouse models, as well as benefits when combined with anti-PDL1 Ab in the B16-OVA model.

物理化学性质&存储条件

分子量	522.48
分子式	C25H23F5N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3,5-difluoro-4-((3-(1-(trifluoromethyl)cyclopropyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)-2,9-dioxa-4-azaspiro[5.5]undec-3-en-3-amine

参考文献

1. Leder, G. et al. Enhancement of anti-tumor T-cell immunity by means of an oral small molecule targeting the intracellular immune checkpoint MAP4K1. Cancer Res. 81 (Suppl. 13), Abstr. 1722 (2021).
2. Mowat J, et al. J Med Chem. 2024 Sep 27. doi: 10.1021/acs.jmedchem.4c01325.

BAY-405 (BAY405)

生物&药学活性

物理化学性质&存储条件

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BAY-405 (BAY405)

生物&药学活性

物理化学性质&存储条件

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