BAY-386 |CAS:1256941-06-6 Probechem Biochemicals

Chemical Structure : BAY-386

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BAY-386 (BAY386)

货号: PC-35139Not For Human Use, Lab Use Only.

BAY-386 (BAY386) is a potent, specific and reversible PAR-1 antagonist with IC50 of 10 nM (HEK cell) and binding IC50 of 56 nM, without affinity for PAR-4 (IC50>10 uM).

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25 mg		Get quote
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1 g		Get quote

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生物&药学活性

BAY-386 (BAY386) is a potent, specific and reversible PAR-1 antagonist with IC50 of 10 nM (HEK cell) and binding IC50 of 56 nM, without affinity for PAR-4 (IC50>10 uM).
BAY-386 inhibits platelet aggregation with IC50 of 0.14 uM.
BAY-386 shows potential for oral treatment of platelet-mediated thrombosis and inflammation.

物理化学性质&存储条件

分子量	514.52
分子式	C22H25F3N4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((3S,5S)-3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)(1,1-dioxidothiomorpholino)methanone

参考文献

1. Christoph Gerdes, et al. Discovery and in vitro pharmacology of BAY-386-a novel, reversible PAR-1 antagonist.

BAY-386 (BAY386)

生物&药学活性

物理化学性质&存储条件

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BAY-386 (BAY386)

生物&药学活性

物理化学性质&存储条件

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