BAY-3827 |CAS:2377576-35-5 Probechem Biochemicals

Chemical Structure : BAY-3827

CAS No.: 2377576-35-5

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BAY-3827 (BAY3827)

货号: PC-35331Not For Human Use, Lab Use Only.

BAY-3827 (BAY3827) is a potent, selective inhibitor of AMPK with IC50 of 0.4 nM (10 µM ATP) and 15 nM (2 mM ATP), respectively.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3680	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BAY-3827 (BAY3827) is a potent, selective inhibitor of AMPK with IC50 of 0.4 nM (10 µM ATP) and 15 nM (2 mM ATP), respectively.
BAY-3827 is a tool compound to evaluate the therapeutic potential of AMPK inhibition in MYC-dependent tumors.
BAY-3827 strongly inhibits Acetyl-CoA carboxylase (ACC) phosphorylation in COLO 320DM and IMR-32 cells, but fails to inhibit the proliferation of cells with dysregulated c-MYC or N-MYC.

物理化学性质&存储条件

分子量	468.536
分子式	C27H25FN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(3,5-dicyano-1,2,6-trimethyl-1,4-dihydropyridin-4-yl)-6-fluoro-7-methyl-1H-indazol-3-yl)-2-ethylbenzamide

参考文献

1. Clara Lemos, et al. Abstract 5873: BAY-3827, a selective inhibitor of AMPK for the evaluation of the role of AMPK in Myc-dependent tumors. AACR.2018.

BAY-3827 (BAY3827)

生物&药学活性

物理化学性质&存储条件

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BAY-3827 (BAY3827)

生物&药学活性

物理化学性质&存储条件

参考文献

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