BAY-155 | menin-MLL inhibitor | Probechem Biochemicals

Chemical Structure : BAY-155

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BAY-155 (BAY155)

货号: PC-38218Not For Human Use, Lab Use Only.

BAY-155 (BAY155) is a novel, potent and selective menin-MLL inhibitor with binding IC50 of 8 nM, 10-fold better compared to that of MI-503.

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生物&药学活性

BAY-155 (BAY155) is a novel, potent and selective menin-MLL inhibitor with binding IC50 of 8 nM, 10-fold better compared to that of MI-503.
BAY-155 demonstrated a significantly enhanced selectivity profile compared to MI-503 in a panel of assays covering numerous safety pharmacology-relevant targets including GPCRs, ion channels and transporters.
BAY-155 shows anti-proliferative activity in a large cell line panel, exhibits specific therapeutic activityin AML/ALL models.

物理化学性质&存储条件

分子量	567.635
分子式	C28H28F3N7OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-cyano-4-methyl-5-((2-(6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)-2,7-diazaspiro[3.5]nonan-7-yl)methyl)-1H-indol-1-yl)acetamide

参考文献

1. Krzysztof Brzezinka, et al. Cancers (Basel). 2020 Jan 14;12(1):201.

BAY-155 (BAY155)

生物&药学活性

物理化学性质&存储条件

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BAY-155 (BAY155)

生物&药学活性

物理化学性质&存储条件

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