BAY-1125976 |CAS:1402608-02-9 Probechem Biochemicals

Chemical Structure : BAY-1125976

CAS No.: 1402608-02-9

加入收藏

BAY-1125976 (BAY1125976)

货号: PC-42032Not For Human Use, Lab Use Only.

BAY-1125976 is a potent and highly selective, allosteric AKT1/2 inhibitor with IC50 of 5.2/18 nM at 10 uM ATP.

规格	价格	库存
5 mg	￥1480	In stock
25 mg	￥3280	In stock
50 mg	￥5480	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

BAY-1125976 is a potent and highly selective, allosteric AKT1/2 inhibitor with IC50 of 5.2/18 nM at 10 uM ATP.
BAY-1125976 binds to active AKT1 with Kd of 2.7 nM and inactive AKT1 with Kd of 1.3 nM.
BAY-1125976 displays >86-fold less potent against AKT3; inhibits the phosphorylation of AKT1 at T308 and S473 (IC50=0.9 and 1.1 nM, respectively), PRAS40 at T246 and 4EBP1 at T70.
BAY-1125976 targets tumors displaying PI3K/AKT/mTOR pathway activation, inhibits cell proliferation in a broad panel of human cancer cell lines, particularly in breast and prostate cancer cell lines expressing estrogen or androgen receptors.
BAY-1125976 exhibits strong in vivo patient-derived xenograft models.

物理化学性质&存储条件

分子量	383.4457
分子式	C23H21N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 10.33 mg/mL
Chemical Name/SMILES	Imidazo[1,2-b]pyridazine-6-carboxamide, 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-

参考文献

1. Politz O, et al. Int J Cancer. 2017 Jan 15;140(2):449-459.

BAY-1125976 (BAY1125976)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

BAY-1125976 (BAY1125976)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.