BAY-091 (BAY091)

Chemical Structure : BAY-091

CAS No.: 2922280-34-8

加入收藏

货号: PC-72463Not For Human Use, Lab Use Only.

BAY-091 (BAY091) is a potent and highly selective inhibitor of PIP4K2A with IC50 of 16 nM in the high ATP (2 mM) HTRF assay.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

BAY-091 (BAY091) is a potent and highly selective inhibitor of PIP4K2A with IC50 of 16 nM in the high ATP (2 mM) HTRF assay.
BAY-091 showed excellent kinase selectivity profile a commercial kinase panel (Millipore, 373 kinases) at 1 uM, none of the potential off-target kinases was inhibited >60%.
BAY-091 displayed drug-like physicochemical properties with favorable lipophilicity (log D), TPSA, and aqueous solubility and exhibited high metabolic stability in human and rat liver microsomes as well as in rat hepatocytes.
BAY-091did not increase the levels of p-AKT (Ser473 and Thr308) in THP-1 cells up to a concentration of 50 uM, also was unable to induce changes in the p-PP2A (Tyr307) protein levels.
BAY-091 is a valuable chemical probe to study PIP4K2A signaling and its involvement in pathophysiological conditions such as cancer.

物理化学性质&存储条件

分子量	440.478
分子式	C26H21FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Butanoic acid, 2-[[3-cyano-2-(2′-fluoro-3′-methyl[1,1′-biphenyl]-4-yl)-1,7-naphthyridin-4-yl]amino]-, (2R)-

参考文献

1. Lars Wortmann, et al. J Med Chem. 2021 Nov 11;64(21):15883-15911.

BAY-091 (BAY091)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

BAY-091 (BAY091)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.