BAY-091 | PIP4K2A inhibitor | Probechem Biochemicals

Chemical Structure : BAY-091

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BAY-091 (BAY091)

货号: PC-72463Not For Human Use, Lab Use Only.

BAY-091 (BAY091) is a potent and highly selective inhibitor of PIP4K2A with IC50 of 16 nM in the high ATP (2 mM) HTRF assay.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BAY-091 (BAY091) is a potent and highly selective inhibitor of PIP4K2A with IC50 of 16 nM in the high ATP (2 mM) HTRF assay.
BAY-091 showed excellent kinase selectivity profile a commercial kinase panel (Millipore, 373 kinases) at 1 uM, none of the potential off-target kinases was inhibited >60%.
BAY-091 displayed drug-like physicochemical properties with favorable lipophilicity (log D), TPSA, and aqueous solubility and exhibited high metabolic stability in human and rat liver microsomes as well as in rat hepatocytes.
BAY-091did not increase the levels of p-AKT (Ser473 and Thr308) in THP-1 cells up to a concentration of 50 uM, also was unable to induce changes in the p-PP2A (Tyr307) protein levels.
BAY-091 is a valuable chemical probe to study PIP4K2A signaling and its involvement in pathophysiological conditions such as cancer.

物理化学性质&存储条件

分子量	440.478
分子式	C26H21FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Butanoic acid, 2-[[3-cyano-2-(2′-fluoro-3′-methyl[1,1′-biphenyl]-4-yl)-1,7-naphthyridin-4-yl]amino]-, (2R)-

参考文献

1. Lars Wortmann, et al. J Med Chem. 2021 Nov 11;64(21):15883-15911.

BAY-091 (BAY091)

生物&药学活性

物理化学性质&存储条件

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BAY-091 (BAY091)

生物&药学活性

物理化学性质&存储条件

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