BAY-0069 | PPARγ inverse agonist | Probechem Biochemicals

Chemical Structure : BAY-0069

CAS No.: 420826-65-9

加入收藏

BAY-0069 (BAY0069)

货号: PC-49400Not For Human Use, Lab Use Only.

BAY-0069 (BAY0069) is a potent, selective, covalent PPARγ inverse agonist with IC50 of 0.22 nM in cellular reporter assays.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4380	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

BAY-0069 (BAY0069) is a potent, selective, covalent PPARγ inverse agonist with IC50 of 0.22 nM in cellular reporter assays.
BAY-0069 displays no signigicant acitivity against PPARA, PPARD and additional high homology PXR (IC50 values >40 uM).
BAY-0069 inhibits proliferation of PPARG-amplified cell line UM-UC-9 with IC50 of 2.5 nM.
In UM-UC-9 xenograft-bearing mice, BAY-0069 demonstrated a modest downregulation of FABP4 expression, comparable with that of SR10221, despite more robust in vitro inverse agonism in NCOR2 recruitment, RT112-FABP4-NLucP luciferase repression, and UM-UC-9 proliferation.

物理化学性质&存储条件

分子量	466.291
分子式	C22H16BrN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-bromo-N-(2-(4-ethylphenyl)benzo[d]oxazol-5-yl)-5-nitrobenzamide

参考文献

1. Douglas L Orsi, et al. J Med Chem. 2022 Oct 21. doi: 10.1021/acs.jmedchem.2c01379.

BAY-0069 (BAY0069)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

BAY-0069 (BAY0069)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.