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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-BAS-2
BAS-2

Chemical Structure : BAS-2

CAS No.: 447410-08-4

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BAS-2

货号: PC-26984Not For Human Use, Lab Use Only.

BAS-2 is a potent, highly selective HDAC6 inhibitor with IC50 of 760 nM (hHDAC6).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BAS-2 is a potent, highly selective HDAC6 inhibitor with IC50 of 760 nM (hHDAC6).
BAS-2 is a prodrug that is preferentially activated by hHDAC6 or N530D zHDAC6 (a humanized variant).
BAS-2 is not efficiently activated by D567N hHDAC6 or wild-type (WT) zHDAC6.
(±)-trans-BAS-2 is more active than cis-BAS-2.

物理化学性质&存储条件

分子量 283.39
分子式 C13H21N3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((3a,4,5,6,7,7a-hexahydro-1H-benzo[d]imidazol-2-yl)thio)-1-morpholinoethan-1-one

参考文献

1. Rodrigues DA, et al. Nat Commun. 2026 Jun 5. doi: 10.1038/s41467-026-73146-5.

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