BAM15 | Mitochondrial uncoupler | Probechem Biochemicals

Chemical Structure : BAM15

CAS No.: 210302-17-3

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BAM15 (Mitochondrial uncoupler BAM15)

货号: PC-38246Not For Human Use, Lab Use Only.

BAM15 (Mitochondrial uncoupler BAM15) is a potent protonophore that uncouples the mitochondria without depolarizing the plasma membrane, oxidative phosphorylation (OXPHOS) uncoupler.

规格	价格	库存
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3480	In stock
100 mg		Get quote

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生物&药学活性

BAM15 (Mitochondrial uncoupler BAM15) is a potent protonophore that uncouples the mitochondria without depolarizing the plasma membrane, oxidative phosphorylation (OXPHOS) uncoupler.
BAM15 attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue.
Compared to FCCP, an uncoupler of equal potency, BAM15 treatment of cultured cells stimulates a higher maximum rate of mitochondrial respiration and is less cytotoxic.
C57BL/6J mice treated with BAM15 were resistant to weight gain.
BAM15-treated mice exhibited improved body composition and glycemic control independent of weight loss, effects attributable to drug targeting of lipid-rich tissues.

物理化学性质&存储条件

分子量	340.294
分子式	C16H10F2N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N5,N6-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine

参考文献

1. Zunica ERM, et al. Cancer Metab. 2021 Oct 9;9(1):36.

2. Dang CP, et al. J Innate Immun. 2021;13(6):359-375.

3. Alexopoulos SJ, et al. Nat Commun. 2020 May 14;11(1):2397.

4. Childress ES, et al. J Med Chem. 2020 Mar 12;63(5):2511-2526.

BAM15 (Mitochondrial uncoupler BAM15)

生物&药学活性

物理化学性质&存储条件

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BAM15 (Mitochondrial uncoupler BAM15)

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物理化学性质&存储条件

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