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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Monopolar Spindle 1 (Mps1/TTK)-BAL0891
BAL0891

Chemical Structure : BAL0891

CAS No.:

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BAL0891

货号: PC-22996Not For Human Use, Lab Use Only.

BAL0891 is a first in class, potent dual TTK/PLK1 inhibitor with IC50 of 0.4/46 nM respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BAL0891 is a first in class, potent dual TTK/PLK1 inhibitor with IC50 of 0.4/46 nM respectively.
BAL0891 elicits a prolonged effect on TTK, with a transient activity on PLK1.
BAL0891 induces spindle assembly checkpoint (SAC) disruption and aberrant mitotic exit.
BAL0891 elicits potent, single agent antitumor activity in TNBC mouse xenograft models.
BAL0891 synergizes with paclitaxel and carboplatin in mouse TNBC models.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Elisa Zanini, et al. Front Oncol. 2024 Aug 9:14:1447807.

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