BAA473 |CAS:20231-68-9 Probechem Biochemicals

Chemical Structure : BAA473

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BAA473 (BAA-473)

货号: PC-36008Not For Human Use, Lab Use Only.

BAA473 (BAA-473) is a bile acid analogue that functions as the first small molecule activator of the Pyrin inflammasome, induces secretion of IL18 in LPS-primed PBMCs.

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生物&药学活性

BAA473 (BAA-473) is a bile acid analogue that functions as the first small molecule activator of the Pyrin inflammasome, induces secretion of IL18 in LPS-primed PBMCs.
BAA473 activates inflammasome in both myeloid and intestinal epithelial cells, the CASP1 inhibitor VX-765 blocked BAA473-induced IL1β production in THP-1 cells.
BAA473 induces cytokine production via ASC/CASP1 but not NLRP3.

物理化学性质&存储条件

分子量	404.591
分子式	C25H40O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (4R)-4-((3R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-12-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

参考文献

1. Alimov I, et al. J Biol Chem. 2019 Jan 15. pii: jbc.RA118.005103.

BAA473 (BAA-473)

生物&药学活性

物理化学性质&存储条件

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BAA473 (BAA-473)

生物&药学活性

物理化学性质&存储条件

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