B3GNT2 inhibitor 8j

Chemical Structure : B3GNT2 inhibitor 8j

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货号: PC-21378Not For Human Use, Lab Use Only.

B3GNT2 inhibitor 8j is a potent, seletive and orally active inhibitor of β-1,3-N-Acetylglucosaminyltransferase 2 (B3GNT2) with IC50 of 9 nM, shows no activity against B3GNT2 (IC50>250 uM).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

B3GNT2 inhibitor 8j is a potent, seletive and orally active inhibitor of β-1,3-N-Acetylglucosaminyltransferase 2 (B3GNT2) with IC50 of 9 nM, shows no activity against B3GNT2 (IC50>250 uM).

物理化学性质&存储条件

分子量	460.46
分子式	C22H23F3N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((R)-3,3-Dimethylbutan-2-yl)-6-((S)-5-methyl-4-oxo-5-(2-(trifluoromethyl)pyrimidin-5-yl)-4,5-dihydro-1H-imidazol-2-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

参考文献

1. Jackson JJ, et al. J Med Chem. 2023 Nov 21. doi: 10.1021/acs.jmedchem.3c01517.