B0AT1 inhibitor compound 3

Chemical Structure : B0AT1 inhibitor compound 3

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货号: PC-27193Not For Human Use, Lab Use Only.

B0AT1 inhibitor compound 3 is a potent, selective, allosteric inhibitor of neutral amino acid transporter B0AT1 (SLC6A19) with IC50 of 513 nM and 295 nM for human and mouse B0AT1 respectively.

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200 mg		Get quote

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B0AT1 inhibitor compound 3 is a potent, selective, allosteric inhibitor of neutral amino acid transporter B0AT1 (SLC6A19) with IC50 of 513 nM and 295 nM for human and mouse B0AT1 respectively.
B0AT1 inhibitor compound 3 shows high binding affinity with Kd of 47.0 nM in cell membrane-binding assays using human B0AT1-ACE2 co-expressing cells.
B0AT1 inhibitor compound 3 preferentially binds to the Na⁺-bound conformation of B0AT1.
B0AT1 inhibitor compound 3 treatment (30 mg/kg, oral) significantly increased urinary phenylalanine (Phe) excretion in phenylketonuria (PKU) model mice.

物理化学性质&存储条件

分子量	355.32
分子式	C16H16F3N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(2-oxo-2-(3-oxopiperazin-1-yl)ethyl)-3-(4-(trifluoromethyl)phenyl)acrylamide

参考文献

1. Takuya Imazu, et al. Commun Biol. 2026 Jun 25. doi: 10.1038/s42003-026-10535-y.