B022 | NIK inhibitor | Probechem Biochemicals

Chemical Structure : B022

CAS No.: 1202764-53-1

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B022 (NIK inhibitor B022)

货号: PC-22722Not For Human Use, Lab Use Only.

B022 is a potent, small-molecule inhibitor of NF-κB-inducing kinase (NIK) with Ki/IC50 of 4.2/15.1 nM, respectively.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

B022 is a potent, small-molecule inhibitor of NF-κB-inducing kinase (NIK) with Ki/IC50 of 4.2/15.1 nM, respectively.
B022 inhibited the NIK signaling pathway, including NIK-induced p100-to-p52 processing and inflammatory gene expression, both in vitro and in vivo.
B022 protected against not only NIK but also CCl4-induced liver inflammation and injury.
B022 prevents NIK- or H(2)O(2)-induced beta cell death and also reduces streptozotocin (STZ)-induced beta cell death.

物理化学性质&存储条件

分子量	397.88
分子式	C19H16ClN5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(1-(2-Amino-5-chloropyrimidin-4-yl)indolin-6-yl)-2-(thiazol-2-yl)but-3-yn-2-ol

参考文献

1. Ren X, et al. FASEB J. 2017 Feb;31(2):711-718.

2. Li X, et al. Mol Ther. 2020 Nov 4;28(11):2430-2441.

B022 (NIK inhibitor B022)

生物&药学活性

物理化学性质&存储条件

参考文献

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B022 (NIK inhibitor B022)

生物&药学活性

物理化学性质&存储条件

参考文献

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