Aβ polymerization stimulator O4 |CAS:71939-12-3 Probechem Biochemicals

Chemical Structure : Aβ polymerization stimulator O4

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Aβ polymerization stimulator O4

货号: PC-62194Not For Human Use, Lab Use Only.

Aβ polymerization stimulator O4 is an orcein-related small molecule can drive polymerization of amyloid-β (Aβ).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

Aβ polymerization stimulator O4 is an orcein-related small molecule can drive polymerization of amyloid-β (Aβ).
Aβ polymerization stimulator O4 directly binds to hydrophobic amino acid residues in Aβ peptides and stabilizes the self-assembly of seeding-competent, β-sheet-rich protofibrils and fibrils, efficiently decreases the concentration of small, toxic Aβ oligomers in complex, heterogeneous aggregation reactions.
Aβ polymerization stimulator O4 suppresses inhibition of long-term potentiation by Aβ oligomers in hippocampal brain slices.

物理化学性质&存储条件

分子量	429.384
分子式	C24H15NO7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,8-bis(2,4-dihydroxyphenyl)-7-hydroxy-3H-phenoxazin-3-one

参考文献

1. Bieschke J, et al. Nat Chem Biol. 2011 Nov 20;8(1):93-101.

2. Sun Y, et al. J Phys Chem B. 2015 Feb 19;119(7):2786-94.