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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Na-K-Cl Cotransporter (NKCC)-Azosemide
Azosemide

Chemical Structure : Azosemide

CAS No.: 27589-33-9

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Azosemide (Azosemidum)

货号: PC-35345Not For Human Use, Lab Use Only.

Azosemide (Azosemidum) is a potent Na-K-Cl Cotransporter NKCC1 with IC50 of 0.246 and 0.197 uM for hNKCC1A and NKCC1B, being about 4-times more potent than bumetanide.

规格 价格 库存 数量
25 mg ￥780 In stock
50 mg ￥1180 In stock
100 mg ￥1980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Azosemide (Azosemidum) is a potent Na-K-Cl Cotransporter NKCC1 with IC50 of 0.246 and 0.197 uM for hNKCC1A and NKCC1B, being about 4-times more potent than bumetanide.
Azosemide is a high-ceiling loop diuretic agent used to treat hypertension, edema, and ascites.

物理化学性质&存储条件

分子量 370.83
分子式 C12H11ClN6O2S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-chloro-5-(2H-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)benzenesulfonamide

参考文献

1. Hampel P, et al. Sci Rep. 2018 Jun 29;8(1):9877.

2. Harada K, et al. J Cardiovasc Pharmacol. 2009 Jun;53(6):468-73.

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