Azo-EMD

Chemical Structure : Azo-EMD

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货号: PC-72726Not For Human Use, Lab Use Only.

Azo-EMD is a cell permeable, photoswitchable compound that inhibits mitotic kinesin Eg5 more potently in its light-induced cis form, used for optical control mitosis.

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生物&药学活性

Azo-EMD is a cell permeable, photoswitchable compound that inhibits mitotic kinesin Eg5 more potently in its light-induced cis form, used for optical control mitosis.
Under UV light conditions, HeLa cells undergo mitotic arrest, as evidenced by the formation of a monopolar spindle.

物理化学性质&存储条件

分子量	656.754
分子式	C37H39F3N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-(methyl(4-((E)-phenyldiazenyl)benzyl)amino)ethyl)-3-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)urea

参考文献

1. Anna C Impastato, et al. Angew Chem Int Ed Engl. 2022 Feb 21;61(9):e202115846.

Azo-EMD

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Azo-EMD

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