Azeloprazole | Proton pump inhibitor | Probechem Biochemicals

Chemical Structure : Azeloprazole

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Azeloprazole (E-3710, Z-215)

货号: PC-60032Not For Human Use, Lab Use Only.

Azeloprazole (E-3710, Z-215) is a potent proton pump inhibitor that irreversibly inhibits H+,K+-ATPase activity with IC50 of 0.28 uM.

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生物&药学活性

Azeloprazole (E-3710, Z-215) is a potent proton pump inhibitor that irreversibly inhibits H+,K+-ATPase activity with IC50 of 0.28 uM.
Azeloprazole inhibits histamine-stimulated gastric acid secretion with ED50 of 0.18-0.2 mg/kg in gastric fistula model in dogs, displays 2.3-fold more potency over Esomeprazole.

物理化学性质&存储条件

分子量	429.535
分子式	C22H27N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(((4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole

参考文献

1. Kodama K, et al. J Pharmacol Exp Ther. 2010 Aug;334(2):395-401.

2. Toda R, et al. J Clin Pharmacol. 2017 Nov 28. doi: 10.1002/jcph.1038.

3. Toda R, et al. Xenobiotica. 2017 Nov 2:1-15. doi: 10.1080/00498254.2017.1390625.

Azeloprazole (E-3710, Z-215)

生物&药学活性

物理化学性质&存储条件

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Azeloprazole (E-3710, Z-215)

生物&药学活性

物理化学性质&存储条件

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