Azeliragon (TTP488, PF-04494700)

Chemical Structure : Azeliragon

CAS No.: 603148-36-3

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货号: PC-45840Not For Human Use, Lab Use Only.

Azeliragon (TTP488, PF-04494700) is an orally bioavailable small molecule inhibitor of RAGE, inhibits sRAGE from binding to RAGE ligands, S100b, amphoterin and carboxymethyl-lysine.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

Azeliragon (TTP488, PF-04494700) is an orally bioavailable small molecule inhibitor of RAGE, inhibits sRAGE from binding to RAGE ligands, S100b, amphoterin and carboxymethyl-lysine.
Azeliragon (TTP488, PF-04494700) has been shown to inhibit the binding of sRAGE to Aβ1-42 in a fluorescent polarization assay.
Azeliragon (TTP488, PF-04494700) reduces accumulation in the spleen of Aβ peptides and the expression of IL-6 and macrophage colony stimulating factor, reduces both inflammatory markers (TNF-α, TGF-β and IL-1) and CNS amyloid deposition.

物理化学性质&存储条件

分子量	532.116
分子式	C32H38ClN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Propanamine, 3-[4-[2-butyl-1-[4-(4-chlorophenoxy)phenyl]-1H-imidazol-4-yl]phenoxy]-N,N-diethyl-

参考文献

1. Sabbagh MN, et al. Alzheimer Dis Assoc Disord. 2011 Jul-Sep;25(3):206-12.

2. Chen Y, et al. J Immunol. 2008 Sep 15;181(6):4272-8.

3. Burstein AH, et al. BMC Neurol. 2014 Jan 15;14:12.