Avotaciclib (BEY1107) | CDK1 inhibitor | Probechem Biochemicals

Chemical Structure : Avotaciclib

CAS No.: 1983983-41-0

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Avotaciclib (BEY1107, BEY-1107)

货号: PC-38340Not For Human Use, Lab Use Only.

Avotaciclib (BEY1107) is a potent, selective CDK1 (Cyclin-Dependent Kinase 1) inhibitor, inhibits self-replication of cancer stem cells and is a candidate for pancreatic cancer treatment.

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5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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生物&药学活性

Avotaciclib (BEY1107) is a potent, selective CDK1 (Cyclin-Dependent Kinase 1) inhibitor, inhibits self-replication of cancer stem cells and is a candidate for pancreatic cancer treatment.
CDK1 is a cell cycle control protein involved in cell division process, blocks G2/M phase in cell division, and eliminates cancer stem cells.
BEY1107 not only controls the cell division of cancer cells but also may overcome the tolerance on anti-cancer drugs with targeting mechanism by eliminating cancer stem cells.
BEY1107 showed synergistic effects of inhibiting metastasis of cancer cell combined with gemcitabine for pancreatic cancer.

物理化学性质&存储条件

分子量	281.279
分子式	C13H11N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,6-bis(2-aminopyrimidin-4-yl)pyridin-3-ol

参考文献

1. Wang Q, et al. NPJ Precis Oncol. 2023 Jun 13;7(1):58.

Avotaciclib (BEY1107, BEY-1107)

生物&药学活性

物理化学性质&存储条件

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Avotaciclib (BEY1107, BEY-1107)

生物&药学活性

物理化学性质&存储条件

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