Avitinib maleate |CAS:1557268-88-8 Probechem Biochemicals

Chemical Structure : Avitinib maleate

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Avitinib maleate (AC-0010MA;AC0010 maleate)

货号: PC-61450Not For Human Use, Lab Use Only.

Avitinib maleate (AC-0010MA, AC0010 maleate) is an orally available, irreversible, and mutant-selective EGFR inhibitor with IC50 of 0.18 nM against EGFR L858R/T790M.

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Avitinib maleate (AC-0010MA, AC0010 maleate) is an orally available, irreversible, and mutant-selective EGFR inhibitor with IC50 of 0.18 nM against EGFR L858R/T790M; displays 43-fold greater potency over wild-type EGFR (IC50=7.68 nM); selectively inhibits mutant EGFR phosphorylation (IC50 =7.3 nM and 2.8 nM) in NCI-H1975 and NIH/3T3_TC32T8 cells, 115- and 298-fold more sensitive than that of the inhibition of wild type EGFR in A431; overcomes T790M-induced resistance in animal models and lung cancer patients without hyperglycemia or other severe adverse effects.

Lung Cancer

Phase 2 Clinical

物理化学性质&存储条件

分子量	603.611
分子式	C30H30FN7O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide maleate

参考文献

1. Xu X, et al. Mol Cancer Ther. 2016 Nov;15(11):2586-2597.

2. Wang W, et al. J Pharm Biomed Anal. 2017 May 30;139:205-214.

Avitinib maleate (AC-0010MA;AC0010 maleate)

生物&药学活性

物理化学性质&存储条件

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Avitinib maleate (AC-0010MA;AC0010 maleate)

生物&药学活性

物理化学性质&存储条件

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