Avasimibe (CI-1011, PD-148515) | ACAT inhibitor | Probechem Biochemicals

Chemical Structure : Avasimibe

CAS No.: 166518-60-1

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Avasimibe (CI-1011, PD-148515, CI1011, PD148515)

货号: PC-43398Not For Human Use, Lab Use Only.

Avasimibe (CI-1011, PD-148515) is a potent, selective inhibitor of acyl-CoA: cholesterol O-acyl transferase (ACAT) with IC50 of 60 nM.

规格	价格	库存
25 mg	￥980	In stock
50 mg	￥1580	In stock
100 mg	￥2580	In stock
250 mg		Get quote

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生物&药学活性

Avasimibe (CI-1011, PD-148515) is a potent, selective inhibitor of acyl-CoA: cholesterol O-acyl transferase (ACAT) with IC50 of 60 nM.
Avasimibe potently reduces plasma cholesterol in chow-fed rats and in rabbits fed a cholesterol-free, casein-containing diet characterized by both hepatic overproduction of apo B-containing lipoproteins and delayed lipoprotein clearance.
Avasimibe decreases both VLDL and LDL apolipoprotein B production in miniature pigs.
Avasimibe synergistically reduces cholesteryl ester content in THP-1 macrophages combined with Atorvastatin,

物理化学性质&存储条件

分子量	501.72102
分子式	C29H43NO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 28 mg/mL
Chemical Name/SMILES	Sulfamic acid, N-[2-[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester

参考文献

1. Lee HT, et al. J Med Chem. 1996 Dec 20;39(26):5031-4.

2. Ramharack R, et al. Atherosclerosis. 1998 Jan;136(1):79-87.

3. Burnett JR, et al. J Lipid Res. 1999 Jul;40(7):1317-27.

4. Llaverías G, et al. Eur J Pharmacol. 2002 Sep 6;451(1):11-7.

Avasimibe (CI-1011, PD-148515, CI1011, PD148515)

生物&药学活性

物理化学性质&存储条件

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Avasimibe (CI-1011, PD-148515, CI1011, PD148515)

生物&药学活性

物理化学性质&存储条件

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