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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Microtubule/Tubulin-Avanbulin
Avanbulin

Chemical Structure : Avanbulin

CAS No.: 798577-91-0

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Avanbulin (BAL27862, BAL-27862)

货号: PC-36086Not For Human Use, Lab Use Only.

Avanbulin (BAL27862, BAL-27862) is a novel microtubule-destabilizing agent that potently inhibits tubulin assembly at 37°C with IC50 of 1.4 uM in tubulin-binding assays.

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10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Avanbulin (BAL27862, BAL-27862) is a novel microtubule-destabilizing agent that potently inhibits tubulin assembly at 37°C with IC50 of 1.4 uM in tubulin-binding assays.
Avanbulin (BAL27862) potently binds to unassembled tubulin with a stoichiometry of 1 mol/mol tubulin and a dissociation constant of 244±30 nM, BAL27862 bound to tubulin independently of vinblastine, without the formation of tubulin oligomers.
Avanbulin (BAL27862) inhibits tumor cell proliferation through activation of the spindle assembly checkpoint, inhibits EB1-dependent migration and invasion and promotes differentiation of glioblastoma stem-like cells both in vitro and in vivo.

物理化学性质&存储条件

分子量 387.403
分子式 C20H17N7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-[(4-{1-[2-(4-aminophenyl)-2-oxoethyl]-1H-benzimidazol-2-yl}-1,2,5-oxadiazol-3-yl)amino]propanenitrile

参考文献

1. Prota AE, et al. J Mol Biol. 2014 Apr 17;426(8):1848-60.

2. Kolb EA, et al. Pediatr Blood Cancer. 2015 Jun;62(6):1106-9.

3. Bergès R, et al. Mol Cancer Ther. 2016 Nov;15(11):2740-2749.

4. Dudka D, et al. Nat Commun. 2018 May 23;9(1):2042.

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