Avacopan | C5aR inhibitor | Probechem Biochemicals

Chemical Structure : Avacopan

CAS No.: 1346623-17-3

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Avacopan (CCX-168, CCX168)

货号: PC-60245Not For Human Use, Lab Use Only.

Avacopan (CCX-168, CCX168) is a potent, selective, orally availale C5aR (CD88) inhibitor with IC50 of 0.1 nM.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
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100 mg		Get quote

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生物&药学活性

Avacopan (CCX-168, CCX168) is a potent, selective, orally availale C5aR (CD88) inhibitor with IC50 of 0.1 nM.
Avacopan (CCX-168, CCX168) shows no activity (IC50 >5,000 nM) for C5aR-related receptors C5L2, C3aR, ChemR23, GPR1 and FPR.
Avacopan (CCX-168, CCX168) inhibits C5a-mediated chemotaxis of U937 cells with pA2 of 0.2 nM.
Avacopan (CCX-168, CCX168) shows activity in mouse model of ANCA-induced glomerulonephritis.

物理化学性质&存储条件

分子量	581.656
分子式	C33H35F4N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3S)-2-(4-(cyclopentylamino)phenyl)-1-(2-fluoro-6-methylbenzoyl)-N-(4-methyl-3-(trifluoromethyl)phenyl)piperidine-3-carboxamide

参考文献

1. Xiao H, et al. J Am Soc Nephrol. 2014 Feb;25(2):225-31.

2. Bekker P, et al. PLoS One. 2016 Oct 21;11(10):e0164646.

3. Jayne DRW, et al. J Am Soc Nephrol. 2017 Sep;28(9):2756-2767.

Avacopan (CCX-168, CCX168)

生物&药学活性

物理化学性质&存储条件

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Avacopan (CCX-168, CCX168)

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