Autotaxin inhibitor 12 |CAS:1613513-14-6 Probechem Biochemicals

Chemical Structure : Autotaxin inhibitor 12

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Autotaxin inhibitor 12

货号: PC-35168Not For Human Use, Lab Use Only.

Autotaxin inhibitor 12 is a highly potent, selective, orally-bioavailable inhibitor of autotaxin with IC50 of 3.1 nM in choline release assays.

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生物&药学活性

Autotaxin inhibitor 12 is a highly potent, selective, orally-bioavailable inhibitor of autotaxin with IC50 of 3.1 nM in choline release assays.
Autotaxin inhibitor 12 shows ATX inhibition of IC50 9 nM in an in vitro serum assay, measuring 18:1 LPA levels by LCMS.
Autotaxin inhibitor 12 concentration-dependently inhibits autotaxin and formation of LPA in vivo.

物理化学性质&存储条件

分子量	440.325
分子式	C19H23Cl2N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,5-dichlorobenzyl 4-(4-(1H-1,2,3-triazol-4-yl)butanamido)piperidine-1-carboxylate

参考文献

1. Thomson CG, et al. Bioorg Med Chem Lett. 2018 May 21. pii: S0960-894X(18)30431-1.