Autoquin | Autophagy inhibitor | Probechem Biochemicals

Chemical Structure : Autoquin

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Autoquin (Autophagy inhibitor)

货号: PC-38229Not For Human Use, Lab Use Only.

Autoquin is a novel autophagy inhibitor (IC50=0.56 uM) by indirect modulation of the activity of the lysosomal enzymes acid sphingomyelinase and acid ceramidase.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Autoquin is a novel autophagy inhibitor (IC50=0.56 uM) by indirect modulation of the activity of the lysosomal enzymes acid sphingomyelinase and acid ceramidase.
Autoquin showed a dose‐dependent inhibition of EGFP‐LC3 puncta after 3 hours upon autophagy induction by amino acid starvation in the primary screening assay.
Autoquin is a lysosomotropic compound that acts as a functional inhibitor of acid sphingomyelinase, increases lysosomal mass and sequesters Fe2+ to the lysosomes in MCF7 cells, causing an increase in lysosomal reactive oxygen species.

物理化学性质&存储条件

分子量	418.512
分子式	C26H27FN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S)-(2-(4-fluorophenyl)-6-methoxyquinolin-4-yl)(5-vinylquinuclidin-2-yl)methanol

参考文献

1. Luca Laraia, et al. Angew Chem Int Ed Engl. 2020 Mar 27;59(14):5721-5729.