Autophazole

Chemical Structure : Autophazole

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货号: PC-72715Not For Human Use, Lab Use Only.

Autophazole is a novel autophagy inhibitor, promotes cancer cell death via caspase activation.

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生物&药学活性

Autophazole is a novel autophagy inhibitor, promotes cancer cell death via caspase activation.
Autophazole was internalized into lysosomes of cells where it induced lysosomal membrane permeabilization (LMP), promoted LMP-mediated apoptosis.
LMP induced by Autophazole caused release of cathepsins from lysosomes into the cytosol. Cathepsins in the cytosol cleaved Bid to generate tBid, which subsequently activated Bax to induce mitochondrial outer membrane permeabilization (MOMP).
Autophazole is a new chemical probe in efforts aimed at gaining a better understanding of the autophagic process.

物理化学性质&存储条件

分子量	659.831
分子式	C40H45N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-4-(1-(4-morpholinophenyl)-4,5-di-p-tolyl-1H-imidazol-2-yl)benzamide

参考文献

1. Sang-Hyun Park, et al. Chembiochem. 2021 Dec 10;22(24):3425-3430.

Autophazole

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Autophazole

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