Autophagy inhibitor EACC | Autophagy inhibitor | Probechem Biochemicals

Chemical Structure : Autophagy inhibitor EACC

CAS No.: 864941-31-1

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Autophagy inhibitor EACC (EACC)

货号: PC-73004Not For Human Use, Lab Use Only.

Autophagy inhibitor EACC (EACC) is a novel small molecule, reversible inhibitor of autophagy, inhibits autophagic flux by blocking autophagosomelysosome fusion.

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生物&药学活性

Autophagy inhibitor EACC (EACC) is a novel small molecule, reversible inhibitor of autophagy, inhibits autophagic flux by blocking autophagosomelysosome fusion.
Unlike other autophagy late stage inhibitors, EACC does not have any effect on lysosomal properties or on endocytosis mediated degradation of EGF receptor.
EACC affects the translocation of SNAREs Stx17 and SNAP29 on autophagosomes without impeding the completion of autophagosomes.
EACC reduces the interaction of Stx17 with the HOPS subunit VPS33A and the cognate lysosomal R-SNARE VAMP8.
Autophagy inhibitor EACC is a useful tool to study autophagosomal SNARE trafficking.

物理化学性质&存储条件

分子量	369.366
分子式	C13H11N3O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethyl (2-(5-nitrothiophene-2-carboxamido) thiophene-3-carbonyl) carbamate

参考文献

1. Vats S, et al. Mol Biol Cell. 2019 Jun 12:mbcE18080482.

Autophagy inhibitor EACC (EACC)

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物理化学性质&存储条件

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Autophagy inhibitor EACC (EACC)

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