AurkinA | Aurora A inhibitor | Probechem Biochemicals

Chemical Structure : AurkinA

加入收藏

AurkinA (Aurkin A, Aurkin-A)

货号: PC-22459Not For Human Use, Lab Use Only.

AurkinA (Aurkin A) is a chemical inhibitor of the AURKA-TPX2 interaction and potent allosteric inhibitor of Aurora A (AURKA), shows binding affinity to AURKA with ITC Kd of 3.77 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

AurkinA (Aurkin A) is a chemical inhibitor of the AURKA-TPX2 interaction and potent allosteric inhibitor of Aurora A (AURKA), shows binding affinity to AURKA with ITC Kd of 3.77 uM.
AurkinA binds to a pocket occupied by Y8 and Y10 of TPX2 in the AURKA-TPX2 complex (the Y-pocket), triggers conformational changes in AURKA protein.
AurkinA inhibits the kinase activity of AURKA in an ATP-independent manner.
AurkinA mislocalises AURKA from the bipolar spindle in mitotic cells.
AurkinA disrupts Alisertib-induced polyploidy in aggressive diffuse large B cell lymphoma.

物理化学性质&存储条件

分子量	346.16
分子式	C16H9BrFNO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-bromophenyl)-8-fluoroquinoline-4-carboxylic acid

参考文献

1. Janeček M, et al. Sci Rep. 2016 Jun 24;6:28528.

2. Lee H, et al. Bioorg Med Chem. 2024 Mar 15;102:117658.

3. Conway PJ, et al. Neoplasia. 2024 Jun 13;55:101014.

AurkinA (Aurkin A, Aurkin-A)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AurkinA (Aurkin A, Aurkin-A)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.