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首页-小分子抑制剂&激动剂-Others-Other Targets-Aurintricarboxylic acid
Aurintricarboxylic acid

Chemical Structure : Aurintricarboxylic acid

CAS No.: 4431-00-9

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Aurintricarboxylic acid (NSC4056)

货号: PC-62361Not For Human Use, Lab Use Only.

NSC4056 (Aurintricarboxylic acid) is a potent, bioactive inhibitor of cystathionine γ-lyase (CSE) with IC5 of 0.6 uM, also is a selective inhibitor of the TWEAK-Fn14 signaling pathway.

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100 mg ￥1980 In stock
200 mg ￥2980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NSC4056 (Aurintricarboxylic acid) is a potent, bioactive inhibitor of cystathionine γ-lyase (CSE) with IC5 of 0.6 uM, also is a selective inhibitor of the TWEAK-Fn14 signaling pathway.
NSC4056 (Aurintricarboxylic acid) selectively binds to Arg and Tyr residues of CSE active site and preferably inhibits the CSE activity in cells rather than cystathionine β-synthase (CBS), the other H2S-generating enzyme.
NSC4056 dose-dependently inhibits endogenous CSE activity and decreases the H2S content in Raw264.7 macrophages.
Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis.
Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway.
Aurintricarboxylic acid also stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells.

物理化学性质&存储条件

分子量 422.34
分子式 C22H14O9
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,4-Cyclohexadiene-1-carboxylic acid, 3-[bis(3-carboxy-4-hydroxyphenyl)methylene]-6-oxo- (7CI,8CI)

参考文献

1. Tan GS, et al. ACS Chem Biol. 2012 Feb 17;7(2):403-10.

2. Hallick RB, et al. Nucleic Acids Res. 1977 Sep;4(9):3055-64.

3. Roos A, et al. Oncotarget. 2017 Feb 14;8(7):12234-12246.

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