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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-Aurachin D
Aurachin D

Chemical Structure : Aurachin D

CAS No.: 108354-13-8

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Aurachin D

货号: PC-28617Not For Human Use, Lab Use Only.

Aurachin D is a smal molecule Mycobacterium tuberculosis (Mtb) cytochrome bd oxidase (Cyt-bd) inhibitor, exhibits inhibitory effects against Gram-positive bacteria and fungi with IC50 value of 0.1 μM against Escherichia coli and IC50 ranging from 0.13 to 33 μM against Mycobacterium tuberculosis, blocks the electron transfer process, disrupts the respiratory chain and energy metabolism of pathogens.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Aurachin D is a smal molecule Mycobacterium tuberculosis (Mtb) cytochrome bd oxidase (Cyt-bd) inhibitor, exhibits inhibitory effects against Gram-positive bacteria and fungi with IC50 value of 0.1 μM against Escherichia coli and IC50 ranging from 0.13 to 33 μM against Mycobacterium tuberculosis, blocks the electron transfer process, disrupts the respiratory chain and energy metabolism of pathogens.

物理化学性质&存储条件

分子量 363.55
分子式 C25H33NO
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Methyl-3-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)quinolin-4(1H)-one

参考文献

1. Lawer A, et al. ACS Med Chem Lett. 2022 Sep 26;13(10):1663-1669.

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