Aumitin |CAS:946293-78-3 Probechem Biochemicals

Chemical Structure : Aumitin

CAS No.: 946293-78-3

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Aumitin

货号: PC-35046Not For Human Use, Lab Use Only.

Aumitin is a novel potent autophagy inhibitor with IC50 of 124 and 244 nM against starvation- and rapamycin- induced autophagy respectively, targets mitochondrial complex I.

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生物&药学活性

Aumitin is a novel potent autophagy inhibitor with IC50 of 124 and 244 nM against starvation- and rapamycin- induced autophagy respectively, targets mitochondrial complex I.
Aumitin inhibits LC3 lipidation, and p62 degradation by starvation- as well as rapamycin-induced autophagy dose-dependently in MCF7-LC3 cells, suggesting inhibition of autophagic flux.
Aumitin inhibits mitochondrial respiration by targeting complex I with IC50 of 0.11 uM in HeLa cells.
Aumitin is a new tool compound for interrogating autophagy and mitochondrial respiration by means of complex I inhibition.

物理化学性质&存储条件

分子量	429.908
分子式	C24H20ClN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N-(4-((4-methyl-6-(phenylamino)pyrimidin-2-yl)amino)phenyl)benzamide

参考文献

1. Robke L, et al. Chem Sci. 2018 Feb 26;9(11):3014-3022.

Aumitin

生物&药学活性

物理化学性质&存储条件

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Aumitin

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