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首页-小分子抑制剂&激动剂-Others-Other Targets-Aulosirazole
Aulosirazole

Chemical Structure : Aulosirazole

CAS No.: 159194-92-0

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Aulosirazole

货号: PC-23018Not For Human Use, Lab Use Only.

Aulosirazole, an isothiazolonaphthoquinone alkaloid, shows cytotoxic activity against OVCAR3 cells (IC50=301 nM), promotes forkhead box O3a (FOXO3a) nuclear accumulation and modulates downstream targets.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Aulosirazole, an isothiazolonaphthoquinone alkaloid, shows cytotoxic activity against OVCAR3 cells (IC50=301 nM), promotes forkhead box O3a (FOXO3a) nuclear accumulation and modulates downstream targets.
Aulosirazole upregulated the FOXO3a target, cyclin-dependent kinase inhibitor 1, and increased cell-cycle arrest in the G0/G1 phase.
Aulosirazole decreased migration and invasion while increasing cell death in 3D tumor spheroids.

物理化学性质&存储条件

分子量 261.25
分子式 C12H7NO4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-hydroxy-3-methoxynaphtho[2,3-d]isothiazole-4,9-dione

参考文献

1. Blunt CE, et al. Angew Chem Int Ed Engl. 2015 Jul 20;54(30):8740-5.

2. Xie Y, et al. Cancers (Basel). 2023 Apr 23;15(9):2424.

3. Khin M, et al. Mol Pharmacol. 2024 Aug 16;106(3):145-154.

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