Atuveciclib |CAS:1414943-88-6 Probechem Biochemicals

Chemical Structure : Atuveciclib

CAS No.: 1414943-88-6

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Atuveciclib (BAY 1143572;BAY1143572)

货号: PC-60537Not For Human Use, Lab Use Only.

Atuveciclib (BAY-1143572) is a potent, highly selective, orally bioavailable CDK9/P-TEFb inhibitor with IC50 of 6 nM for CDK9/CyclinT1.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

Atuveciclib (BAY-1143572) is a potent, highly selective, orally bioavailable CDK9/P-TEFb inhibitor with IC50 of 6 nM for CDK9/CyclinT1.
Atuveciclib displays >150-fold selectivity over CDK1/2/3/5/6/7 (IC50>800 nM), also shows submicromolar inhibitory activity against GSK3α (IC50=45 nM), GSK3β (IC50=87 nM).
Atuveciclib demonstrates antiproliferative activity against HeLa cells (IC50=920 nM) and MOLM‐13 cells (IC50=310 nM).
Atuveciclib exhibits anticancer activity in human AML models.

物理化学性质&存储条件

分子量	387.433
分子式	C18H18FN5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-((4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl)amino)benzyl)(imino)(methyl)-l6-sulfanone

参考文献

1. Lücking U, et al. ChemMedChem. 2017 Nov 8;12(21):1776-1793.

2. Narita T, et al. Blood. 2017 Aug 31;130(9):1114-1124.

Atuveciclib (BAY 1143572;BAY1143572)

生物&药学活性

物理化学性质&存储条件

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Atuveciclib (BAY 1143572;BAY1143572)

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物理化学性质&存储条件

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