Atopaxar hydrobromide |CAS:474550-69-1 Probechem Biochemicals

Chemical Structure : Atopaxar hydrobromide

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Atopaxar hydrobromide (E5555 hydrobromide)

货号: PC-61308Not For Human Use, Lab Use Only.

Atopaxar hydrobromide (E5555) is a potent, reversible protease-activated receptor-1 (PAR-1) antagonist with IC50 of 19 nM.

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生物&药学活性

Atopaxar hydrobromide (E5555) is a potent, reversible protease-activated receptor-1 (PAR-1) antagonist with IC50 of 19 nM.
Atopaxar (E5555) shows potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC50 of 64 nM and 31 nM, respectively, with no effect on platelet aggregation induced by either ADP or collagen.
Atopaxar (E5555) inhibits arterial thrombosis without affecting bleeding time in photochemically-induced thrombosis model guinea pigs.

物理化学性质&存储条件

分子量	608.54
分子式	C29H38FN3O5.HBr
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5,6-Diethoxy-7-fluoro-1,3-dihydro-1-imino-2H-isoindol-2-yl)-1-[3-(1,1-dimethylethyl)-4-methoxy-5-(4-morpholinyl)phenyl]ethanone hydrobromide

参考文献

1. Serebruany VL, et al. Thromb Haemost. 2009 Jul;102(1):111-9.

2. Angiolillo DJ, et al. Eur Heart J. 2010 Jan;31(1):17-28.

3. Kogushi M, et al. Eur J Pharmacol. 2011 Apr 25;657(1-3):131-7.

Atopaxar hydrobromide (E5555 hydrobromide)

生物&药学活性

物理化学性质&存储条件

参考文献

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Atopaxar hydrobromide (E5555 hydrobromide)

生物&药学活性

物理化学性质&存储条件

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