Atopaxar |CAS:751475-53-3 Probechem Biochemicals

Chemical Structure : Atopaxar

CAS No.: 751475-53-3

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Atopaxar (E-5555;E5555)

货号: PC-61307Not For Human Use, Lab Use Only.

Atopaxar (E5555) is a potent, reversible protease-activated receptor-1 (PAR-1) antagonist with IC50 of 19 nM.

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100 mg	￥6980	In stock
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1 g		Get quote

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生物&药学活性

Atopaxar (E5555) is a potent, reversible protease-activated receptor-1 (PAR-1) antagonist with IC50 of 19 nM.
Atopaxar (E5555) shows potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC50 of 64 nM and 31 nM, respectively, with no effect on platelet aggregation induced by either ADP or collagen.
Atopaxar (E5555) inhibits arterial thrombosis without affecting bleeding time in photochemically-induced thrombosis model guinea pigs.

物理化学性质&存储条件

分子量	527.6374
分子式	C29H38FN3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5,6-Diethoxy-7-fluoro-1,3-dihydro-1-imino-2H-isoindol-2-yl)-1-[3-(1,1-dimethylethyl)-4-methoxy-5-(4-morpholinyl)phenyl]ethanone

参考文献

1. Serebruany VL, et al. Thromb Haemost. 2009 Jul;102(1):111-9.

2. Angiolillo DJ, et al. Eur Heart J. 2010 Jan;31(1):17-28.

3. Kogushi M, et al. Eur J Pharmacol. 2011 Apr 25;657(1-3):131-7.

Atopaxar (E-5555;E5555)

生物&药学活性

物理化学性质&存储条件

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Atopaxar (E-5555;E5555)

生物&药学活性

物理化学性质&存储条件

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