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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Monoamine Transporter-Atomoxetine hydrochloride
Atomoxetine hydrochloride

Chemical Structure : Atomoxetine hydrochloride

CAS No.: 82248-59-7

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Atomoxetine hydrochloride (Tomoxetine, LY-139603)

货号: PC-63053Not For Human Use, Lab Use Only.

Atomoxetine hydrochloride((R)-Tomoxetine LY-139603) is a potent, selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Atomoxetine hydrochloride((R)-Tomoxetine LY-139603) is a potent, selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM.
Atomoxetine shows weak affinity for 5-HT and dopamine transporters with IC50 of 77 and 1,451 nM, respectively.
Atomoxetine has been approved for the treatment of attention deficit hyperactivity disorder (ADHD).

物理化学性质&存储条件

分子量 291.819
分子式 C17H22ClNO
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine hydrochloride

参考文献

1. Bymaster FP, et al. Neuropsychopharmacology. 2002 Nov;27(5):699-711.

2. Sauer JM, et al. Clin Pharmacokinet. 2005;44(6):571-90.

3. Passamonti L, et al. Psychopharmacology (Berl). 2017 Aug;234(15):2289-2297.

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