Chemical Structure : Atibuclimab
CAS No.: 2417175-94-9
货号: PC-Ab1060Not For Human Use, Lab Use Only.
Atibuclimab (IC14) is a chimeric CD14 antibody investigated for the treatment of patients with severe sepsis. Human monocyte differentiation antigen CD14 is a pattern recognition receptor (PRR) that enhances innate immune responses. Atibuclimab (IC14) attenuated the LPS-induced release of MIP-1beta, but not of MIP-1alpha. IL-8 and MCP-1, but not MIP-1alpha and MIP-1b, circulate in RBC-associated form during endotoxemia..
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥3580 | In stock | |
5 mg | ¥7580 | In stock | |
10 mg | ¥12800 | In stock | |
100 mg | Get quote |
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Atibuclimab (IC14) is a chimeric CD14 antibody investigated for the treatment of patients with severe sepsis. Human monocyte differentiation antigen CD14 is a pattern recognition receptor (PRR) that enhances innate immune responses. Atibuclimab (IC14) attenuated the LPS-induced release of MIP-1beta, but not of MIP-1alpha. IL-8 and MCP-1, but not MIP-1alpha and MIP-1b, circulate in RBC-associated form during endotoxemia.
分子量 | ||
分子式 | Human IgG4-Kappa | |
外观性状 | Solid | |
储存条件 |
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Solubility |
PBS, pH 7.0 Contains no stabilizers or preservatives |
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Chemical Name/SMILES |
Atibuclimab; IC14; anti CD14; soluble CD14 antibody; antigen CD14; LPS R; Cluster of differentiation 14 |
1. 1, Reinhart K, et al. Crit Care Med. 2004 May;32(5):1100-8. 2, Verbon A, et al. J Infect Dis. 2003 Jan 1;187(1):55-61. 3, Genth-Zotz S, et al. Eur J Heart Fail. 2006 Jun;8(4):366-72. 4, Spek CA, et al. J Clin Immunol. 2003 Mar;23(2):132-40. 5, Marongiu L, et al. Sci Signal. 2021 Mar 30;14(676):eaaz2120.
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