Atglistatin

Chemical Structure : Atglistatin

CAS No.: 1469924-27-3

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货号: PC-20903Not For Human Use, Lab Use Only.

Atglistatin is a selective adipose triglyceride lipase (ATGL) inhibitor, inhibits lipolysis in living cells with IC50 of 0.7 uM, directly inhibits ATGL in a competitive manner with Ki of 355 nM.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
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生物&药学活性

Atglistatin is a selective adipose triglyceride lipase (ATGL) inhibitor, inhibits lipolysis in living cells with IC50 of 0.7 uM, directly inhibits ATGL in a competitive manner with Ki of 355 nM.
Atglistatin does not inhibit HSL, MGL, pancreatic lipase, lipoprotein lipase, PNPLA6 and PNPLA7.
Atglistatin does not cause cardiac TG accumulation, despite inhibition of lipolysis.
Atglistatin is a tool compound to study the pathophysiology and druggability of ATGL in animal models of metabolic disease and cachexia.

物理化学性质&存储条件

分子量	283.38
分子式	C17H21N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[4'-(Dimethylamino)-biphenyl-3-yl]-1,1-dimethylurea

参考文献

1. Mayer N, et al. Nat Chem Biol. 2013 Dec;9(12):785-7.

2. Cerk IK, et al. J Biol Chem. 2014 Nov 21;289(47):32559-70.

Atglistatin

生物&药学活性

物理化学性质&存储条件

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Atglistatin

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