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Atazanavir

Chemical Structure : Atazanavir

CAS No.: 198904-31-3

Atazanavir (BMS-232632, BMS232632)

货号: PC-45186Not For Human Use, Lab Use Only.

Atazanavir (BMS-232632) is a highly potent HIV-1 protease inhibitor that exhibits potent anti-HIV activity EC50 of 2.6-5.3 nM and EC90 of 9-15 nM in cell culture.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Atazanavir (BMS-232632) is a highly potent HIV-1 protease inhibitor that exhibits potent anti-HIV activity EC50 of 2.6-5.3 nM and EC90 of 9-15 nM in cell culture.
Atazanavir (BMS-232632) shows synergistic antiviral effects in HIV-infected PBMCs.
Atazanavir (BMS-232632) is used to treat and prevent HIV/AIDS.

物理化学性质&存储条件

分子量 704.8555
分子式 C38H52N6O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2,5,6,10,13-Pentaazatetradecanedioic acid, 3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-, 1,14-dimethyl ester, (3S,8S,9S,12S)-

参考文献

1. Robinson BS, et al. Antimicrob Agents Chemother. 2000 Aug;44(8):2093-9.

2. Gong YF, et al. Antimicrob Agents Chemother. 2000 Sep;44(9):2319-26.

3. Drusano GL, et al. J Infect Dis. 2001 Apr 1;183(7):1126-9.

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