Ataciguat sodium |CAS:254976-06-2 Probechem Biochemicals

Chemical Structure : Ataciguat sodium

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Ataciguat sodium (HMR-1766;HMR1766)

货号: PC-61608Not For Human Use, Lab Use Only.

Ataciguat (HMR-1766) is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.51 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC.

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生物&药学活性

Ataciguat (HMR-1766) is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.51 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC; increases cGMP levels in cultured rat aortic smooth muscle cells; induces vasorelaxation of isolated endothelium-denuded rat aorta, porcine coronary arteries, and human corpus cavernosum with EC50 of 1-10 uM; decreases arterial blood pressure in anesthetized pigs.

Heart Failure

Phase 2 Clinical

物理化学性质&存储条件

分子量	598.46
分子式	C21H18Cl2N3NaO6S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-chloro-2-[(5-chlorothiophen-2-yl)sulfonylamino]-N-(4-morpholin-4-ylsulfonylphenyl)benzamide sodium salt

参考文献

1. Schindler U, et al. Mol Pharmacol. 2006 Apr;69(4):1260-8.

2. Evgenov OV, et al. Nat Rev Drug Discov. 2006 Sep;5(9):755-68.

3. Schäfer A, et al. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2813-8.

4. Zhou Z, et al. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1763-71.

Ataciguat sodium (HMR-1766;HMR1766)

生物&药学活性

物理化学性质&存储条件

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Ataciguat sodium (HMR-1766;HMR1766)

生物&药学活性

物理化学性质&存储条件

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