Asapiprant | DP1 antagonist | Probechem Biochemicals

Chemical Structure : Asapiprant

CAS No.: 932372-01-5

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Asapiprant (S-555739, S555739)

货号: PC-22638Not For Human Use, Lab Use Only.

Asapiprant (S-555739) is a potent and selective prostaglandin DP1 receptor antagonist with Ki of 0.44 nM, >300-fold selective over EP2 and other prostanoid receptors.

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10 mg	￥4380	In stock
25 mg	￥7280	In stock
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生物&药学活性

Asapiprant (S-555739) is a potent and selective prostaglandin DP1 receptor antagonist with Ki of 0.44 nM, >300-fold selective over EP2 and other prostanoid receptors.
Asapiprant (S-555739) strongly inhibits the cAMP elevation elicited by PGD2 in human platelets with IC50 of 16 nM, 50-fold than another DP1 antagonist, S-5751 (840 nM).
Asapiprant (S-555739) inhibits cAMP elevation induced by PGD2 in guinea pigs, rats, and sheep with IC50 of 61, 74, and 15, respectively.
Asapiprant (S-555739) (3, 5 mg/kg) inhibits PGD2-induced nasal resistance (sRaw) in guinea pigs.
Asapiprant (S-555739) suppresses antigen-induced asthmatic responses, airway hyper-responsiveness, and cell infiltration and mucin production in lung.

物理化学性质&存储条件

分子量	501.55
分子式	C24H27N3O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[2-(Oxazol-2-yl)-5-(4-{4-[(propan-2-yl)oxy]phenylsulfonyl}piperazine-1-yl)phenoxy] acetic acid

参考文献

1. Takahashi G, et al. Eur J Pharmacol. 2015 Oct 15;765:15-23.

Asapiprant (S-555739, S555739)

生物&药学活性

物理化学性质&存储条件

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Asapiprant (S-555739, S555739)

生物&药学活性

物理化学性质&存储条件

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