Arylsulfonamide 64B | HIF inhibitor | Probechem Biochemicals

Chemical Structure : Arylsulfonamide 64B

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Arylsulfonamide 64B (HIF inhibitor 64B)

货号: PC-72329Not For Human Use, Lab Use Only.

Arylsulfonamide 64B (HIF inhibitor 64B) is a small molecule inhibitor of HIF pathway, blocks hypoxia-induced expression of c-Met and CXCR4 and uveal melanoma (UM) cell migration.

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生物&药学活性

Arylsulfonamide 64B (HIF inhibitor 64B) is a small molecule inhibitor of HIF pathway, blocks hypoxia-induced expression of c-Met and CXCR4 and uveal melanoma (UM) cell migration.
64B inhibited hypoxia-inducible gene expression (c-Met/CXCR4) in Mel290-V6R cells stably expressing an HRE-driven luciferase reporter gene.
64B blocks HIF transcriptional activity by disrupting the interaction between HIF-1α and p300, independently of Factor inhibiting HIF-1 (FIH-1), directly binds to p300 and interferes with p300 recruitment to HIF-1 activated MET and CXCR4 genes.
64B inhibits primary tumor growth, liver metastasis formation, and prolongs survival in orthotopic mice models of uveal melanoma.

物理化学性质&存储条件

分子量	444.546
分子式	C23H28N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-Cyclobutyl-N-[(2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl]-3,4-dimethoxybenzenesulfonamide

参考文献

1. Lei Dong, et al. Clin Cancer Res. 2019 Apr 1;25(7):2206-2218.

Arylsulfonamide 64B (HIF inhibitor 64B)

生物&药学活性

物理化学性质&存储条件

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Arylsulfonamide 64B (HIF inhibitor 64B)

生物&药学活性

物理化学性质&存储条件

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