Artepillin C | CREB/CRTC2 inhibitor | Probechem Biochemicals

Chemical Structure : Artepillin C

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Artepillin C (CREB-CRTC2 inhibitor APC)

货号: PC-72794Not For Human Use, Lab Use Only.

Artepillin C (CREB-CRTC2 inhibitor APC) is an inhibitor of CREB/CRTC2 interaction (IC50=24.5 uM), dissociates the CREB/CRTC2 complex, directly binds to CREB with Kd of 3.2 uM).

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生物&药学活性

Artepillin C (CREB-CRTC2 inhibitor APC) is an inhibitor of CREB/CRTC2 interaction (IC50=24.5 uM), dissociates the CREB/CRTC2 complex, directly binds to CREB with Kd of 3.2 uM.
CREB-CRTC2 inhibitor APC inhibits CRTC2 interacting with CREB-ZIP and reduces acetyltransferase activity of CBP by binding with CREB protein directly.
Artepillin C attenuated gluconeogenesis in primary hepatocytes, reduced glucose output from primary hepatocytes induced by glucagon, remarkably decreased the mRNA accumulation of G6pc, Pck1, and Pgc-1α induced by glucagon in primary hepatocytes.|
Artepillin C could ameliorate hyperlipidemia in obese mice.

物理化学性质&存储条件

分子量	300.398
分子式	C19H24O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3, 5-diprenyl-4-hydroxycinnamic acid

参考文献

1. Yaqiong Chen, et al. Nat Commun. 2022 Jan 11;13(1):246.

Artepillin C (CREB-CRTC2 inhibitor APC)

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物理化学性质&存储条件

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Artepillin C (CREB-CRTC2 inhibitor APC)

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物理化学性质&存储条件

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